EPHA4 |
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Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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2LW8, 2WO1, 2WO2, 2WO3, 3CKH, 3GXU, 4BK4, 4BK5, 4BKA, 4BKF, 4M4P, 4M4R, 4W4Z, 4W50, 5JR2 |
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Identifiers |
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Aliases | EPHA4, Epha4, 2900005C20Rik, AI385584, Cek8, Hek8, Sek, Sek1, Tyro1, rb, EPH receptor A4, HEK8, SEK, TYRO1, EK8 |
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External IDs | OMIM: 602188; MGI: 98277; HomoloGene: 20933; GeneCards: EPHA4; OMA:EPHA4 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 2 (human)[1] |
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| Band | 2q36.1 | Start | 221,418,027 bp[1] |
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End | 221,574,202 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 1 (mouse)[2] |
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| Band | 1 C4|1 39.55 cM | Start | 77,343,822 bp[2] |
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End | 77,491,725 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - Brodmann area 23
- frontal pole
- middle temporal gyrus
- lateral nuclear group of thalamus
- endothelial cell
- primary visual cortex
- superior frontal gyrus
- parietal lobe
- postcentral gyrus
- palpebral conjunctiva
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| Top expressed in | - Rostral migratory stream
- medial ganglionic eminence
- ventricular zone
- dorsal striatum
- genital tubercle
- dentate gyrus of hippocampal formation granule cell
- medial dorsal nucleus
- lateral geniculate nucleus
- nucleus accumbens
- tail of embryo
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| More reference expression data |
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BioGPS |
| More reference expression data |
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Gene ontology |
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Molecular function | - transferase activity
- protein kinase activity
- nucleotide binding
- GPI-linked ephrin receptor activity
- ephrin receptor binding
- DH domain binding
- transmembrane-ephrin receptor activity
- kinase activity
- protein binding
- identical protein binding
- transmembrane receptor protein tyrosine kinase activity
- PH domain binding
- protein tyrosine kinase activity
- ATP binding
- ephrin receptor activity
- amyloid-beta binding
- protein tyrosine kinase binding
| Cellular component | - cytoplasm
- axon terminus
- integral component of membrane
- cell body
- perikaryon
- postsynaptic membrane
- Golgi apparatus
- endosome
- cell projection
- early endosome membrane
- membrane
- postsynaptic density
- filopodium
- neuromuscular junction
- plasma membrane
- dendritic spine
- axonal growth cone
- integral component of plasma membrane
- synapse
- cell surface
- mitochondrial outer membrane
- cell junction
- axon
- dendrite
- early endosome
- endoplasmic reticulum
- neuron projection
- dendritic shaft
- receptor complex
- Schaffer collateral - CA1 synapse
- glutamatergic synapse
- integral component of postsynaptic membrane
- integral component of presynaptic membrane
| Biological process | - negative regulation of axon regeneration
- fasciculation of motor neuron axon
- phosphorylation
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of JUN kinase activity
- regulation of GTPase activity
- nervous system development
- regulation of axonogenesis
- multicellular organism development
- protein phosphorylation
- regulation of astrocyte differentiation
- cell adhesion
- positive regulation of dendrite morphogenesis
- nephric duct morphogenesis
- protein autophosphorylation
- corticospinal tract morphogenesis
- peptidyl-tyrosine phosphorylation
- fasciculation of sensory neuron axon
- motor neuron axon guidance
- positive regulation of Rho guanyl-nucleotide exchange factor activity
- regulation of dendritic spine morphogenesis
- glial cell migration
- adult walking behavior
- axon guidance
- ephrin receptor signaling pathway
- negative regulation of neuron projection development
- protein stabilization
- positive regulation of protein tyrosine kinase activity
- neuron projection guidance
- synapse pruning
- neuron projection fasciculation
- negative regulation of long-term synaptic potentiation
- positive regulation of amyloid-beta formation
- positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
- negative regulation of proteolysis involved in cellular protein catabolic process
- cellular response to amyloid-beta
- regulation of modification of synaptic structure
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001304536 NM_001304537 NM_004438 NM_001363748 |
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RefSeq (protein) | |
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NP_001291465 NP_001291466 NP_004429 NP_001350677 |
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Location (UCSC) | Chr 2: 221.42 – 221.57 Mb | Chr 1: 77.34 – 77.49 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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