Oxotremorine
Chemical compound
- C
administration
- none
- US: Experimental/not yet approved
- 1-(4-Pyrrolidin-1-ylbut-2-yn-1-yl)pyrrolidin-2-one
- 70-22-4 Y
- 302
- 4469 N
- 5RY0UWH1JL
- ChEMBL7634 N
- DTXSID10220252
- Interactive image
- C1CCN(C1)CC#CCN2CCCC2=O
InChI
- InChI=InChI=1S/C12H18N2O/c15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13/h1-2,5-11H2 N
- Key:RSDOPYMFZBJHRL-UHFFFAOYSA-N N
Oxotremorine is a drug that acts as a selective muscarinic acetylcholine receptor agonist.[1]
Oxotremorine produces ataxia, tremor and spasticity, similar to those symptoms seen in Parkinsonism, and has thus become a research tool in experimental studies aimed at determining more effective anti-Parkinsonian drugs.[2]
Oxotremorine also produces antipsychotic effects.[3]
References
- ^ Tang C, Castoldi AF, Costa LG (April 1993). "Effects of the muscarinic agonist oxotremorine on membrane fluidity in rat lymphocytes". Biochemistry and Molecular Biology International. 29 (6): 1047–54. PMID 8330013. INIST 4025194.
- ^ Craig CR, Stitzel RE, eds. (2004). Modern Pharmacology with Clinical Applications. Lippincott Williams & Wilkins. ISBN 978-0-7817-3762-3.[page needed]
- ^ Maehara S, Hikichi H, Satow A, Okuda S, Ohta H (November 2008). "Antipsychotic property of a muscarinic receptor agonist in animal models for schizophrenia". Pharmacology, Biochemistry, and Behavior. 91 (1): 140–9. doi:10.1016/j.pbb.2008.06.023. PMID 18651995. S2CID 12225821. INIST 20678587.
See also
- Tremorine
- v
- t
- e
Muscarinic acetylcholine receptor modulators
(and prodrugs)
- See also
- Receptor/signaling modulators
- Nicotinic acetylcholine receptor modulators
- Acetylcholine metabolism/transport modulators
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