ADRA2A |
---|
|
Наявні структури |
---|
PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 1HLL, 1HO9, 1HOD, 1HOF | | |
Ідентифікатори |
---|
Символи | ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32, adrenoceptor alpha 2A |
---|
Зовнішні ІД | OMIM: 104210 MGI: 87934 HomoloGene: 47944 GeneCards: ADRA2A |
---|
|
Реагує на сполуку |
---|
apraclonidine, guanabenz, адреналін, brimonidine, норадреналін, апоморфін, клонідин, dexmedetomidine, guanfacine, оксиметазолін, pergolide, xylazine, brl-44408, бромокриптин, каберголін, хлорпромазин, lisuride, lurasidone, міртазапін, Фентоламін, пірибедил, празозин, α-yohimbine, spiroxatrine, terguride, tolazoline, WB-4101, yohimbine, levonordefrin, адреналін, норадреналін, Ефедрин, apraclonidine hydrochloride, dipivefrin hydrochloride, oxymetazoline hydrochloride, phenoxybenzamine hydrochloride, dexmedetomidine hydrochloride[1] |
Онтологія гена |
---|
Молекулярна функція | • alpha-2C adrenergic receptor binding • G protein-coupled receptor activity • protein homodimerization activity • epinephrine binding • norepinephrine binding • alpha-1B adrenergic receptor binding • signal transducer activity • adrenergic receptor activity • GO:0001948, GO:0016582 protein binding • alpha2-adrenergic receptor activity • protein heterodimerization activity • thioesterase binding • heterotrimeric G-protein binding • protein kinase binding |
---|
Клітинна компонента | • integral component of membrane • мембрана • receptor complex • клітинна мембрана • integral component of plasma membrane • basolateral plasma membrane • цитоплазма |
---|
Біологічний процес | • G protein-coupled receptor signaling pathway • positive regulation of epidermal growth factor-activated receptor activity • activation of protein kinase B activity • negative regulation of insulin secretion • positive regulation of MAP kinase activity • negative regulation of epinephrine secretion • glucose homeostasis • regulation of smooth muscle contraction • GO:0032737 positive regulation of cytokine production • regulation of insulin secretion • positive regulation of cell migration • positive regulation of potassium ion transport • phospholipase C-activating adrenergic receptor signaling pathway • positive regulation of wound healing • negative regulation of norepinephrine secretion • positive regulation of membrane protein ectodomain proteolysis • negative regulation of insulin secretion involved in cellular response to glucose stimulus • adenylate cyclase-inhibiting adrenergic receptor signaling pathway • negative regulation of calcium ion transmembrane transporter activity • cellular response to hormone stimulus • regulation of vasoconstriction • negative regulation of calcium ion-dependent exocytosis • Rho protein signal transduction • positive regulation of cell population proliferation • negative regulation of calcium ion transport • intestinal absorption • Ras protein signal transduction • negative regulation of lipid catabolic process • activation of protein kinase activity • actin cytoskeleton organization • GO:0072468 сигнальна трансдукція • platelet activation • positive regulation of MAPK cascade • adrenergic receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-activating adrenergic receptor signaling pathway • receptor transactivation • adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
---|
Джерела:Amigo / QuickGO | |
Шаблон експресії |
---|
|
Більше даних |
Ортологи |
---|
Види | Людина | Миша |
---|
Entrez | | |
---|
Ensembl | | |
---|
UniProt | | |
---|
RefSeq (мРНК) | | |
---|
RefSeq (білок) | | |
---|
Локус (UCSC) | Хр. 10: 111.08 – 111.08 Mb | Хр. 19: 54.03 – 54.04 Mb |
---|
PubMed search | [2] | [3] |
---|
Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
|