ENG |
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Ідентифікатори |
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Символи | ENG, Eng, AI528660, AI662476, CD105, Endo, S-endoglin, END, HHT1, ORW1, endoglin |
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Зовнішні ІД | OMIM: 131195 MGI: 95392 HomoloGene: 92 GeneCards: ENG |
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Пов'язані генетичні захворювання |
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хвороба Рандю — Ослера[1] |
Онтологія гена |
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Молекулярна функція | • type I transforming growth factor beta receptor binding • protein homodimerization activity • activin binding • transforming growth factor beta-activated receptor activity • galactose binding • glycosaminoglycan binding • BMP binding • GO:0001948, GO:0016582 protein binding • transforming growth factor beta binding • transmembrane signaling receptor activity • type II transforming growth factor beta receptor binding • identical protein binding |
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Клітинна компонента | • integral component of membrane • мембрана • focal adhesion • receptor complex • endothelial microparticle • external side of plasma membrane • cell surface • міжклітинний простір • клітинна мембрана |
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Біологічний процес | • cell migration involved in endocardial cushion formation • response to hypoxia • GO:0009373 regulation of transcription, DNA-templated • negative regulation of nitric-oxide synthase activity • negative regulation of protein autophosphorylation • venous blood vessel morphogenesis • cell motility • positive regulation of pathway-restricted SMAD protein phosphorylation • regulation of phosphorylation • extracellular matrix disassembly • positive regulation of systemic arterial blood pressure • Загоєння ран • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of transforming growth factor beta receptor signaling pathway • BMP signaling pathway • negative regulation of pathway-restricted SMAD protein phosphorylation • positive regulation of angiogenesis • negative regulation of endothelial cell proliferation • васкулогенез • heart looping • heart development • regulation of cell adhesion • адгезія клітин • negative regulation of cell migration • regulation of cell population proliferation • Ангіогенез • artery morphogenesis • central nervous system vasculogenesis • smooth muscle tissue development • positive regulation of BMP signaling pathway • branching involved in blood vessel morphogenesis • cell chemotaxis • transforming growth factor beta receptor signaling pathway • cell migration • detection of hypoxia • regulation of transforming growth factor beta receptor signaling pathway • GO:1901313 positive regulation of gene expression • regulation of cardiac muscle cell apoptotic process • bone development • positive regulation of protein phosphorylation • endocardial cushion to mesenchymal transition • sprouting angiogenesis • response to corticosteroid • extracellular matrix constituent secretion • regulation of cell proliferation involved in heart morphogenesis • response to transforming growth factor beta • positive regulation of collagen biosynthetic process • cellular response to mechanical stimulus • outflow tract septum morphogenesis • epithelial to mesenchymal transition involved in endocardial cushion formation • endocardial cushion morphogenesis • cardiac ventricle morphogenesis • cardiac atrium morphogenesis • ventricular trabecula myocardium morphogenesis • negative regulation of gene expression • dorsal aorta morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • atrial cardiac muscle tissue morphogenesis • vascular associated smooth muscle cell development • positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation • positive regulation of vascular associated smooth muscle cell differentiation • atrioventricular canal morphogenesis • regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis • positive regulation of protein kinase B signaling |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_000118 NM_001114753 NM_001278138 |
| | NM_001146348 NM_001146350 NM_007932 |
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RefSeq (білок) | | NP_000109 NP_001108225 NP_001265067 NP_001108225.1 NP_001265067.1 |
| | NP_001139820 NP_001139822 NP_031958 |
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Локус (UCSC) | Хр. 9: 127.82 – 127.85 Mb | Хр. 2: 32.54 – 32.57 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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