TLR4 |
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Наявні структури |
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PDB | Пошук ортологів: PDBe RCSB | Список кодів PDB | 4G8A, 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA | | |
Ідентифікатори |
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Символи | TLR4, ARMD10, CD284, TLR-4, TOLL, toll like receptor 4 |
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Зовнішні ІД | OMIM: 603030 MGI: 96824 HomoloGene: 41317 GeneCards: TLR4 |
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Реагує на сполуку |
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resatorvid[1] |
Онтологія гена |
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Молекулярна функція | • lipopolysaccharide immune receptor activity • lipopolysaccharide binding • GO:0001948, GO:0016582 protein binding • transmembrane signaling receptor activity |
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Клітинна компонента | • цитоплазма • мембрана • perinuclear region of cytoplasm • cell surface • integral component of membrane • клітинна мембрана • endosome membrane • intrinsic component of plasma membrane • integral component of plasma membrane • lipopolysaccharide receptor complex • external side of plasma membrane |
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Біологічний процес | • positive regulation of MHC class II biosynthetic process • positive regulation of JNK cascade • TRIF-dependent toll-like receptor signaling pathway • cellular response to mechanical stimulus • positive regulation of interleukin-8 production • positive regulation of ERK1 and ERK2 cascade • T-helper 1 type immune response • positive regulation of platelet activation • positive regulation of interleukin-1 production • positive regulation of stress-activated MAPK cascade • positive regulation of NLRP3 inflammasome complex assembly • positive regulation of interleukin-12 production • positive regulation of interferon-alpha production • I-kappaB phosphorylation • positive regulation of nitric-oxide synthase biosynthetic process • positive regulation of B cell proliferation • defense response to bacterium • positive regulation of interleukin-6 production • activation of innate immune response • positive regulation of tumor necrosis factor production • negative regulation of tumor necrosis factor production • вроджений імунітет • negative regulation of interleukin-17 production • I-kappaB kinase/NF-kappaB signaling • positive regulation of interferon-beta production • positive regulation of inflammatory response • toll-like receptor 4 signaling pathway • positive regulation of macrophage cytokine production • positive regulation of interleukin-10 production • процес імунної системи • astrocyte development • intestinal epithelial structure maintenance • positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway • response to lipopolysaccharide • cellular response to lipoteichoic acid • positive regulation of NF-kappaB transcription factor activity • GO:0046730, GO:0046737, GO:0046738, GO:0046736 імунна відповідь • negative regulation of interleukin-23 production • regulation of inflammatory response • positive regulation of chemokine production • lipopolysaccharide-mediated signaling pathway • detection of fungus • positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway • negative regulation of interferon-gamma production • response to bacterium • negative regulation of osteoclast differentiation • B cell proliferation involved in immune response • positive regulation of nitric oxide biosynthetic process • negative regulation of interleukin-6 production • positive regulation of interferon-gamma production • nitric oxide production involved in inflammatory response • MyD88-dependent toll-like receptor signaling pathway • regulation of dendritic cell cytokine production • GO:1901313 positive regulation of gene expression • negative regulation of ERK1 and ERK2 cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • macrophage activation • detection of lipopolysaccharide • cellular response to lipopolysaccharide • positive regulation of lymphocyte proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • MyD88-independent toll-like receptor signaling pathway • GO:0072468 сигнальна трансдукція • inflammatory response • GO:0051636 defense response to Gram-negative bacterium • toll-like receptor signaling pathway • GO:0060554, GO:0060555 Некроптоз • apoptotic signaling pathway • negative regulation of MyD88-independent toll-like receptor signaling pathway |
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Джерела:Amigo / QuickGO | |
Шаблон експресії |
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Більше даних |
Ортологи |
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Види | Людина | Миша |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (мРНК) | | NM_138557 NM_003266 NM_138554 NM_138556 |
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RefSeq (білок) | | NP_003257 NP_612564 NP_612567 |
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Локус (UCSC) | Хр. 9: 117.7 – 117.72 Mb | Хр. 4: 66.75 – 66.85 Mb |
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PubMed search | [2] | [3] |
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Вікідані |
Див./Ред. для людей | Див./Ред. для мишей |
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